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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on the practical aspects of the study design, such as the recruitment process and consent in adherence, 프라그마틱 공식홈페이지 [Brewwiki.Win] as well as the use of standard equipment.

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Pragmatic is a software company that provides a variety of casino games available on online gambling platforms. Its iGaming software is used by the top operators as well as casinos that are located in the land. The company offers front-end tools for design, analysis, marketing, promotions payment systems, security, customer service, and bug reporting. Additionally, the company offers its players a secure environment with high-quality graphics as well as games.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographical regions. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps reduce the chance of bias in the results. Too much heterogeneity, however could cause issues with the trial design.

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The purpose of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually ordered by policymakers and practitioners to guide their decisions. They can be used to determine the causality of an intervention with its outcomes. They should not, however be used to replace explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study that includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.