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Pragmatic trials are studies designed to inform real-world clinical practice. They are often described as focusing on practical aspects of design, including recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for practical trials to be valid and reduces the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. They are typically commissioned by policymakers and practitioners to help inform their decisions. They can be used to determine the causality of an intervention and its results. However, they should not be used as a substitute for explanation trials.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or 프라그마틱 정품확인방법 if they are a complement to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the features of a practical trial which includes the recruitment process, the design and 프라그마틱 카지노 implementation of the intervention, and the follow-up.

There is a positive trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatics. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.